Toxic Metal Species and ‘Endogenous’ Metalloproteins at the Blood–Organ Interface: Analytical and Bioinorganic Aspects

Globally, human exposure to environmental pollutants causes an estimated 9 million deaths per year and it could also be implicated in the etiology of diseases that do not appear have a genetic origin. Accordingly, there is need gain information about biomolecular mechanisms causally link inorganic with distinct adverse health effects. Although analysis blood plasma red cell (RBC) cytosol can provide important biochemical these mechanisms, inherent complexity biological matrices make this difficult task. In perspective, we will examine use metalloentities are present RBC as potential biomarkers assess pollutants. Our primary objective explore principal bioinorganic processes contribute increased or decreased metalloprotein concentrations and/or cytosol. Furthermore, identify metabolites which form bloodstream contain essential well toxic metals for biomarkers. While latter metal species represent useful short-term exposure, endogenous metalloproteins indicators long-term individual Based on considerations, quantification identified feasible research avenue better understand effects associated chronic various populations Exposure likely increase consequence technological advances, including fast-growing applications metal-based engineering nanomaterials.